Article
Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations.
PloS one - 19 Feb 2010
Tuch Brian B, Laborde Rebecca R, Xu Xing, Gu Jian, Chung Christina B, Monighetti Cinna K, Stanley Sarah J, Olsen Kerry D, Kasperbauer Jan L, Moore Eric J, Broomer Adam J, Tan Ruoying, Brzoska Pius M, Muller Matthew W, Siddiqui Asim S, Asmann Yan W, Sun Yongming, Kuersten Scott, Barker Melissa A, De La Vega Francisco M, Smith David I
Abstract excerpt
Due to growing throughput and shrinking cost, massively parallel sequencing is rapidly becoming an attractive alternative to microarrays for the genome-wide study of gene expression and copy number alterations in primary tumors. The sequencing of transcripts (RNA-Seq) should offer several advanta...
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