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Article

Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations.

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2010

Bellacosa Alfonso, Godwin Andrew K, Peri Suraj, Devarajan Karthik, Caretti Elena, Vanderveer Lisa, Bove Betsy, Slater Carolyn, Zhou Yan, Daly Mary, Howard Sharon, Campbell Kerry S, Nicolas Emmanuelle, Yeung Anthony T, Clapper Margie L, Crowell James A, Lynch Henry T, Ross Eric, Kopelovich Levy, Knudson Alfred G

Abstract excerpt

We hypothesized that cells bearing a single inherited "hit" in a tumor suppressor gene express an altered mRNA repertoire that may identify targets for measures that could delay or even prevent progression to carcinoma. We report here on the transcriptomes of primary breast and ovarian epithelial...

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Source

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Identifiers

PMID: 20051372
DOI: 10.1158/1940-6207.CAPR-09-0078
PMCID: PMC2804937

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20051372-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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