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Article

TGF-beta1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype.

Immunity - 1 May 1998

King C, Davies J, Mueller R, Lee M S, Krahl T, Yeung B, O'Connor E, Sarvetnick N

Abstract excerpt

TGF-beta1, expressed in the pancreatic islets, protects the nonobese diabetic (NOD) mouse from insulin-dependent diabetes mellitus (IDDM). The islet antigen-specific T cell response of ins-TGF-beta1 mice relied on different antigen-presenting cells (APC) from those used by NOD T cells. T cells from NOD mice utilized B cells to present islet antigen, whereas T cells from ins-TGF-beta1 mice utilized macrophages. In...

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Identifiers

PMID: 9620681
DOI: 10.1016/s1074-7613(00)80565-8

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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