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Article

Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production.

Journal of molecular endocrinology - 1 Feb 2011

Uruno Akira, Matsuda Ken, Noguchi Naoya, Yoshikawa Takeo, Kudo Masataka, Satoh Fumitoshi, Rainey William E, Hui Xiao-Gang, Akahira Jun-ichi, Nakamura Yasuhiro, Sasano Hironobu, Okamoto Hiroshi, Ito Sadayoshi, Sugawara Akira

Abstract excerpt

Peroxisome proliferator-activated receptor-γ (PPARγ) is a nuclear receptor for the antidiabetic agent thiazolidinedione, which exerts various physiological activities, independent of lowering blood glucose. However, the role of PPARγ in aldosterone production has not been clarified. The objective of this study was to investigate the effect of PPARγ on aldosterone synthase gene (CYP11B2) expression and aldosterone...

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Identifiers

PMID: 21106862
DOI: 10.1677/JME-10-0088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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