Article
Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonists.
Endocrinology - 1 Jun 2002
Gerhold David L, Liu Franklin, Jiang Guoqiang, Li Zhihua, Xu Jian, Lu Meiqing, Sachs Jeffrey R, Bagchi Ansuman, Fridman Arthur, Holder Daniel J, Doebber Thomas W, Berger Joel, Elbrecht Alex, Moller David E, Zhang Bei B
Abstract excerpt
PPAR gamma is an adipocyte-specific nuclear hormone receptor. Agonists of PPAR gamma, such as thiazolidinediones (TZDs), promote adipocyte differentiation and have insulin-sensitizing effects in animals and diabetic patients. Affymetrix oligonucleotide arrays representing 6347 genes were employed to profile the gene expression responses of mature 3T3-L1 adipocytes and differentiating preadipocytes to a TZD PPAR...
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