Article
Pleiotropic actions of PPAR gamma activators thiazolidinediones in cardiovascular diseases.
Current pharmaceutical design - 1 Jan 2004
Takano Hiroyuki, Hasegawa Hiroshi, Zou Yunzeng, Komuro Issei
Abstract excerpt
Peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the nuclear receptor superfamily and form heterodimers with retinoid X receptor. To date, three PPARs isoforms have been isolated and termed alpha, beta (or delta), and gamma. Although PPAR gamma is expressed predominantly in adipose tissue and associated with adipocyte differentiation and glucose homeostasis, it has been...
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