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Article

Calmodulin-Dependent Kinase I Regulates Adrenal Cell Expression of Aldosterone Synthase

29 Aug 2002

Abstract excerpt

Aldosterone synthase (CYP11B2) is expressed in the adrenal glomerulosa and controls the capacity of the adrenal glomerulosa to produce aldosterone. Herein, human NCI-H295R (H295R) adrenocortical cells were used to define the calcium-dependent mechanisms regulating CYP11B2 gene transcription using reporter constructs containing CYP11B2 gene 5'-flanking DNA. Treatment of H295R cells with...

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Identifiers

PMID: 12193581
DOI: 10.1210/en.2001-211359

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