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Article

Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese.

PloS one - 17 Nov 2010

Hu Cheng, Zhang Rong, Wang Congrong, Wang Jie, Ma Xiaojing, Hou Xuhong, Lu Jingyi, Yu Weihui, Jiang Feng, Bao Yuqian, Xiang Kunsan, Jia Weiping

Abstract excerpt

BACKGROUND: Recent meta-analysis of genome-wide association studies in European descent samples identified novel loci influencing glucose and insulin related traits. In the current study, we aimed to evaluate the association between these loci and traits related to glucose metabolism in the Chinese. METHODS/PRINCIPAL FINDINGS: We genotyped seventeen single nucleotide polymorphisms (SNPs) from fifteen loci...

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Source

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Identifiers

PMID: 21103350
DOI: 10.1371/journal.pone.0015542
PMCID: PMC2984505

Genes

MADD
PROX1
CRY2
DGKB
GIPR
GLIS3
IGF1
ADCY5
FADS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese.PMID 21103350Read ↗

Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans.Semantic proximity Read ↗

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.Semantic proximity Read ↗

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.Semantic proximity Read ↗

Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits.Semantic proximity Read ↗

PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.Semantic proximity Read ↗

Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population.Semantic proximity Read ↗

Heritability and genome-wide association analyses of fasting plasma glucose in Chinese adult twins.Semantic proximity Read ↗

Genome-wide analysis study of gestational diabetes mellitus and related pathogenic factors in a Chinese Han population.Semantic proximity Read ↗

Rs2227982 and rs2227981 in PDCD1 gene are functional SNPs associated with T1D risk in East Asian.Semantic proximity Read ↗

Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study.Semantic proximity Read ↗

Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin.Semantic proximity Read ↗

Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.Semantic proximity Read ↗

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