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Article

PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

PloS one - 28 Oct 2009

Hu Cheng, Zhang Rong, Wang Congrong, Wang Jie, Ma Xiaojing, Lu Jingyi, Qin Wen, Hou Xuhong, Wang Chen, Bao Yuqian, Xiang Kunsan, Jia Weiping

Abstract excerpt

BACKGROUND: Recent advance in genetic studies added the confirmed susceptible loci for type 2 diabetes to eighteen. In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism. METHODS/PRINCIPAL FINDINGS: Twenty-one single nucleotide polymorphisms (SNPs) from fourteen loci were successfully genotyped in...

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Source

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Identifiers

PMID: 19862325
DOI: 10.1371/journal.pone.0007643
PMCID: PMC2763267

Genes

CDKAL1
HHEX
IDE
KCNJ11
KIF11
PPARG
ADAM30
ADAMTS9
FTO
JAZF1
NOTCH2
TSPAN8
WFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.PMID 19862325Read ↗

Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.Semantic proximity Read ↗

Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.Semantic proximity Read ↗

Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.Semantic proximity Read ↗

Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.Semantic proximity Read ↗

Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.Semantic proximity Read ↗

Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies.Semantic proximity Read ↗

Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.Semantic proximity Read ↗

Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore.Semantic proximity Read ↗

Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.Semantic proximity Read ↗

Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.Semantic proximity Read ↗

Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.Semantic proximity Read ↗

Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.Semantic proximity Read ↗

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