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Article

Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits.

Journal of human genetics - 1 Dec 2012

Fujita Hayato, Hara Kazuo, Shojima Nobuhiro, Horikoshi Momoko, Iwata Minoru, Hirota Yushi, Tobe Kazuyuki, Seino Susumu, Kadowaki Takashi

Abstract excerpt

The aim of the present study was to explore the role of variations with modest effects (previously identified by a large-scale meta-analysis in European populations) in the genetic background of type 2 diabetes (T2D) and diabetes-related traits in a Japanese population. We enrolled 2632 Japanese subjects with T2D and 2050 non-diabetic subjects. We analyzed nine single-nucleotide polymorphisms (SNPs), including...

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Source

Identifiers

PMID: 22992776
DOI: 10.1038/jhg.2012.110

Genes

FADS1
PROX1
CRY2
DGKB
GCK
GLIS3
IGF1

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