Article
Identification of novel candidate genes for Alzheimer's disease by autozygosity mapping using genome wide SNP data.
Journal of Alzheimer's disease : JAD - 1 Jan 2011
Sherva Richard, Baldwin Clinton T, Inzelberg Rivka, Vardarajan Badri, Cupples L Adrienne, Lunetta Kathryn, Bowirrat Abdalla, Naj Adam, Pericak-Vance Margaret, Friedland Robert P, Farrer Lindsay A
Abstract excerpt
Alzheimer's disease (AD) is highly prevalent in Wadi Ara despite the low frequency of apolipoprotein E ε4 in this genetically isolated Arab community in northern Israel. We hypothesized that the reduced genetic variability in combination with increased homozygosity would facilitate identification...
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