Article
Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample.
American journal of human genetics - 1 Oct 2005
Rademakers Rosa, Cruts Marc, Sleegers Kristel, Dermaut Bart, Theuns Jessie, Aulchenko Yurii, Weckx Stefan, De Pooter Tim, Van den Broeck Marleen, Corsmit Ellen, De Rijk Peter, Del-Favero Jurgen, van Swieten John, van Duijn Cornelia M, Van Broeckhoven Christine
Abstract excerpt
We obtained conclusive linkage of Alzheimer disease (AD) with a candidate region of 19.7 cM at 7q36 in an extended multiplex family, family 1270, ascertained in a population-based study of early-onset AD in the northern Netherlands. Single-nucleotide polymorphism and haplotype association analyses of a Dutch patient-control sample further supported the linkage at 7q36. In addition, we identified a shared...
Topics
- Aged
- Alzheimer Disease
- Chromosomes, Human, Pair 7
- Female
- Genetic Linkage
- Genetics, Population
- Humans
- Male
- Middle Aged
- Netherlands