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Article

Whole genome analysis in a consanguineous family with early onset Alzheimer's disease.

Neurobiology of aging - 1 Dec 2009

Clarimón J, Djaldetti R, Lleó A, Guerreiro R J, Molinuevo J L, Paisán-Ruiz C, Gómez-Isla T, Blesa R, Singleton A, Hardy J

Abstract excerpt

Early-onset Alzheimer's disease (EOAD) is a clinically and genetically heterogeneous condition in which the typical features appear significantly earlier in life (before 65 years). Mutations in three genes (PSEN1, PSEN2, and APP) have been identified in autosomal dominant forms of EOAD. However, in about 50% of Mendelian cases and in most of the sporadic EOAD patients, no mutations have been found. We present...

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Source

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Identifiers

PMID: 18387709
DOI: 10.1016/j.neurobiolaging.2008.02.008
PMCID: PMC8950082

Genes

APP
PSEN1
PSEN2
PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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