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Article

Examination of candidate exonic variants for association to Alzheimer disease in the Amish.

PloS one - 1 Jan 2015

D'Aoust Laura N, Cummings Anna C, Laux Renee, Fuzzell Denise, Caywood Laura, Reinhart-Mercer Lori, Scott William K, Pericak-Vance Margaret A, Haines Jonathan L

Abstract excerpt

Alzheimer disease (AD) is the most common cause of dementia. As with many complex diseases, the identified variants do not explain the total expected genetic risk that is based on heritability estimates for AD. Isolated founder populations, such as the Amish, are advantageous for genetic studies as they overcome heterogeneity limitations associated with complex population studies. We determined that Amish AD...

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Identifiers

PMID: 25668194
DOI: 10.1371/journal.pone.0118043
PMCID: PMC4323242

Genes

LAMA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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