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Article

A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses.

The Journal of biological chemistry - 21 Jan 2011

Marinis Jill M, Homer Craig R, McDonald Christine, Abbott Derek W

Abstract excerpt

The Crohn's disease and early onset sarcoidosis susceptibility protein, NOD2, coordinates innate immune signaling pathways. Because dysregulation of this coordination can lead to inflammatory disease, maintaining appropriate activation of the NOD2 signaling pathway is paramount in immunologic hom...

Read the complete abstract on PubMed

Topics

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Share to Amino Acid Motifs
Share to Crohn Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to NF-kappa B

Share to Nod2 Signaling Adaptor Protein

Share to Salmonella Infections

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Source

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Identifiers

PMID: 21097508
DOI: 10.1074/jbc.M110.189308
PMCID: PMC3023490

Genes

NOD2
TRAF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21097508-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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