Article
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing.
Science (New York, N.Y.) - 4 Feb 2005
Maeda Shin, Hsu Li-Chung, Liu Hongjun, Bankston Laurie A, Iimura Mitsutoshi, Kagnoff Martin F, Eckmann Lars, Karin Michael
Abstract excerpt
Variants of NOD2, an intracellular sensor of bacteria-derived muramyl dipeptide (MDP), increase susceptibility to Crohn's disease (CD). These variants are thought to be defective in activation of nuclear factor kappaB (NF-kappaB) and antibacterial defenses, but CD clinical specimens display elevated NF-kappaB activity. To illuminate the pathophysiological function of NOD2, we introduced such a variant to the...
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