Polymorphism at the HLA-DQ locus determines susceptibility to experimental autoimmune myasthenia gravis.

Article

Polymorphism at the HLA-DQ locus determines susceptibility to experimental autoimmune myasthenia gravis.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 1998

Raju R, Zhan W Z, Karachunski P, Conti-Fine B, Sieck G C, David C

Abstract excerpt

Studies in myasthenia gravis (MG) patients demonstrate that polymorphism at the HLA-DQ locus influences the development of MG. Several studies using the mouse models also demonstrate the influence of class II molecules, especially the H2-A, which is the mouse homologue of HLA-DQ, in experimental...

Topics

Animals
Genetic Predisposition to Disease
HLA-DQ Antigens
Humans
Mice
Mice, Transgenic
Myasthenia Gravis
Polymorphism, Genetic

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