Article
Polymorphism at the HLA-DQ locus determines susceptibility to experimental autoimmune myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 1998
Raju R, Zhan W Z, Karachunski P, Conti-Fine B, Sieck G C, David C
Abstract excerpt
Studies in myasthenia gravis (MG) patients demonstrate that polymorphism at the HLA-DQ locus influences the development of MG. Several studies using the mouse models also demonstrate the influence of class II molecules, especially the H2-A, which is the mouse homologue of HLA-DQ, in experimental autoimmune myasthenia gravis (EAMG). We used transgenic mice expressing two different DQ molecules, DQ8...
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