Article
Targeting the antigen-binding site of HLA-restricting alleles in treatment of autoimmune disease.
Critical reviews in immunology - 1 Jan 2007
Oshima Minako, Deitiker Philip, Atassi M Zouhair
Abstract excerpt
In autoimmune disease, production of disease-causing auto-antibodies (Abs) depends on autoreactive T cells that recognize the epitopes of the pathogenic antigen in the context of MHC class II molecules. It is possible that selective inhibition of an antigen-presenting function of disease-associated MHC alleles could lead to suppression of the disease. Myasthenia gravis (MG) is a disabling neuromuscular disease in...
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