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Article

Human mineralocorticoid receptor (MR) gene haplotypes modulate MR expression and transactivation: implication for the stress response.

Psychoneuroendocrinology - 1 Jun 2011

van Leeuwen Nienke, Bellingrath Silja, de Kloet E Ronald, Zitman Frans G, DeRijk Roel H, Kudielka Brigitte M, Wüst Stefan

Abstract excerpt

Stress causes activation of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in secretion of corticosteroids which facilitate behavioural adaptation. These effects exerted by corticosteroids are mediated by two brain corticosteroid receptor types, the mineralocorticoid receptor (MR), with...

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Source

Identifiers

PMID: 21095064
DOI: 10.1016/j.psyneuen.2010.10.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21095064-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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