Article
Human mineralocorticoid receptor (MR) gene haplotypes modulate MR expression and transactivation: implication for the stress response.
Psychoneuroendocrinology - 1 Jun 2011
van Leeuwen Nienke, Bellingrath Silja, de Kloet E Ronald, Zitman Frans G, DeRijk Roel H, Kudielka Brigitte M, Wüst Stefan
Abstract excerpt
Stress causes activation of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in secretion of corticosteroids which facilitate behavioural adaptation. These effects exerted by corticosteroids are mediated by two brain corticosteroid receptor types, the mineralocorticoid receptor (MR), with a high affinity already occupied under basal conditions and the glucocorticoid receptor (GR), with a low affinity only...
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