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Article

The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation.

Clinical epigenetics - 1 Jan 2016

Li-Tempel Ting, Larra Mauro F, Sandt Estelle, Mériaux Sophie B, Schote Andrea B, Schächinger Hartmut, Muller Claude P, Turner Jonathan D

Abstract excerpt

BACKGROUND: Gender, genetic makeup, and prior experience interact to determine physiological responses to an external perceived stressor. Here, we investigated the contribution of both genetic variants and promoter methylation of the NR3C1 (glucocorticoid receptor) gene to the cardiovascular and hypothalamus-pituitary-adrenal (HPA) axis response to the socially evaluated cold pressor test (seCPT). RESULTS: Two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26823689
DOI: 10.1186/s13148-016-0180-y
PMCID: PMC4730588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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