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Article

Interaction of the N-terminus of ecdysone receptor isoforms with the ligand-binding domain.

Molecular and cellular endocrinology - 30 Jan 2011

Tremmel Ch, Schaefer M, Azoitei A, Ruff H, Spindler-Barth M

Abstract excerpt

Ecdysone receptor (EcR) isoforms exert different biological functions, although they vary only in their N-terminal domain. Despite identical C-termini, which mediate hormone-induced activity, the influence of ligand is isoform specific, which indicates an N/C-interaction. The position of helix 12 with and without hormone varies among isoforms and modifies N/C-interaction determined by fluorescence...

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PMID: 21094674
DOI: 10.1016/j.mce.2010.11.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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