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Article

Analysis of transcriptional activity mediated by Drosophila melanogaster ecdysone receptor isoforms in a heterologous cell culture system.

Insect molecular biology - 1 Dec 2006

Beatty J, Fauth T, Callender J L, Spindler-Barth M, Henrich V C

Abstract excerpt

Ecdysteroid regulation of gene transcription in Drosophila melanogaster and other insects is mediated by a heterodimer comprised of Ultraspiracle (USP) and one of three ecdysone receptor (EcR) isoforms (A, B1 and B2). This study revealed that the EcR/USP heterodimer displays isoform-specific capabilities. EcRB1 is normally induced with a form of USP that is missing its DNA-binding domain (DBD), although...

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PMID: 17201771
DOI: 10.1111/j.1365-2583.2006.00683.x

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