Article
The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2005
Schaufele Fred, Carbonell Xavier, Guerbadot Martin, Borngraeber Sabine, Chapman Mark S, Ma Aye Aye K, Miner Jeffrey N, Diamond Marc I
Abstract excerpt
Nuclear receptors (NRs) are ligand-regulated transcription factors important in human physiology and disease. In certain NRs, including the androgen receptor (AR), ligand binding to the carboxy-terminal domain (LBD) regulates transcriptional activation functions in the LBD and amino-terminal domain (NTD). The basis for NTD-LBD communication is unknown but may involve NTD-LBD interactions either within a single...
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