Article
Transcription activation by the ecdysone receptor (EcR/USP): identification of activation functions.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 2003
Hu Xiao, Cherbas Lucy, Cherbas Peter
Abstract excerpt
The ecdysone receptor is a heterodimer of the two nuclear receptors EcR and ultraspiracle (USP). We have identified the regions of Drosophila EcR and USP responsible for transcriptional activation of a semisynthetic Eip71CD promoter in Kc cells. The isoform-specific A/B domains of EcR-B1 and B2, but not those of EcR-A or USP, exhibit strong activation activity [activation function 1 (AF1)], both in isolation and...
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