Article
Muscle type-specific responses to NAD+ salvage biosynthesis promote muscle function in Caenorhabditis elegans.
Developmental biology - 15 Jan 2011
Vrablik Tracy L, Wang Wenqing, Upadhyay Awani, Hanna-Rose Wendy
Abstract excerpt
Salvage biosynthesis of nicotinamide adenine dinucleotide (NAD(+)) from nicotinamide (NAM) lowers NAM levels and replenishes the critical molecule NAD(+) after it is hydrolyzed. This pathway is emerging as a regulator of multiple biological processes. Here we probe the contribution of the NAM-NAD(+) salvage pathway to muscle development and function using Caenorhabditis elegans. C. elegans males with mutations in...
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