Article
Caenorhabditis elegans development requires mitochondrial function in the nervous system.
Biochemical and biophysical research communications - 9 Jul 2004
Ndegwa Sarah, Lemire Bernard D
Abstract excerpt
The mitochondrial respiratory chain (MRC) supplies the majority of the energy requirements of most eucaryotic cells. A null mutation in the Caenorhabditis elegans nuo-1 gene encoding a subunit of complex I (NADH-ubiquinone oxidoreductase) is lethal, leading to a developmental arrest at the third larval stage. To identify the tissues that regulate development in response to mitochondrial dysfunction, we restored...
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