Article

Increased mitochondrial Ca <sup>2+</sup> contributes to health decline with age and Duchene muscular dystrophy in <i>C. elegans</i>

2022-07-08

Abstract excerpt

<h4>Summary</h4> Sarcopenia is a geriatric syndrome characterized by an age-related decline in skeletal muscle mass and strength. Here, we show that suppression of mitochondrial calcium uniporter (MCU)-mediated Ca 2+ influx into mitochondria in the body wall muscles of the nematode Caenorhabditis elegans improved the sarcopenic phenotypes, blunting movement and mitochondrial structural and functional decline wi...

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Literature Corpus work: f3c878af-55d0-5f9b-98cb-08679c598efb
DOI: 10.1101/2022.07.08.499319

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