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Article

NAD+ Biosynthesis Ameliorates a Zebrafish Model of Muscular Dystrophy

23 Oct 2012

Abstract excerpt

Muscular dystrophies are common, currently incurable diseases. A subset of dystrophies result from genetic disruptions in complexes that attach muscle fibers to their surrounding extracellular matrix microenvironment. Cell-matrix adhesions are exquisite sensors of physiological conditions and mediate responses that allow cells to adapt to changing conditions. Thus, one approach towards finding targets for future...

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PMID: 23109907
DOI: 10.1371/journal.pbio.1001409

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