Article
Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation.
The Journal of biological chemistry - 25 Feb 1990
Countaway J L, McQuilkin P, Gironès N, Davis R J
Abstract excerpt
The major sites of serine and threonine phosphorylation of the human epidermal growth factor (EGF) receptor observed in intact cells are Thr654, Thr669, Ser1046, and Ser1047. Phosphorylation of the EGF receptor is increased at these sites in cells treated with platelet-derived growth factor or ph...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Cell Line
- DNA Replication
- Epidermal Growth Factor
- ErbB Receptors
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Peptide Fragments
- Phosphopeptides
- Phosphorylation
- Plasmids
- Platelet-Derived Growth Factor
- Serine
- Threonine