Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23.

doi:10.1093/eurheartj/ehq405

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Article

Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23.

European heart journal - 1 Jan 2011

Erdmann Jeanette, Willenborg Christina, Nahrstaedt Janja, Preuss Michael, König Inke R, Baumert Jens, Linsel-Nitschke Patrick, Gieger Christian, Tennstedt Stephanie, Belcredi Petra, Aherrahrou Zouhair, Klopp Norman, Loley Christina, Stark Klaus, Hengstenberg Christian, Bruse Petra, Freyer Jennifer, Wagner Arnika K, Medack Anja, Lieb Wolfgang, Grosshennig Anika, Sager Hendrik B, Reinhardt Adrian, Schäfer Arne, Schreiber Stefan, El Mokhtari Nour Eddine, Raaz-Schrauder Dorette, Illig Thomas, Garlichs Christoph D, Ekici Arif B, Reis André, Schrezenmeir Jürgen, Rubin Diana, Ziegler Andreas, Wichmann H-E, Doering Angela, Meisinger Christa, Meitinger Thomas, Peters Annette, Schunkert Heribert

Abstract excerpt

AIMS: Recent genome-wide association (GWA) studies identified 10 chromosomal loci for coronary artery disease (CAD) or myocardial infarction (MI). However, these loci explain only a small proportion of the genetic variability of these pertinent diseases. We sought to identify additional CAD/MI loci by applying a three-stage approach. METHODS AND RESULTS: We genotyped n = 1157 MI cases and n = 1748 controls from a...

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PMID: 21088011
DOI: 10.1093/eurheartj/ehq405

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