Article
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
Nature genetics - 1 Sept 2017
Nelson Christopher P, Goel Anuj, Butterworth Adam S, Kanoni Stavroula, Webb Tom R, Marouli Eirini, Zeng Lingyao, Ntalla Ioanna, Lai Florence Y, Hopewell Jemma C, Giannakopoulou Olga, Jiang Tao, Hamby Stephen E, Di Angelantonio Emanuele, Assimes Themistocles L, Bottinger Erwin P, Chambers John C, Clarke Robert, Palmer Colin N A, Cubbon Richard M, Ellinor Patrick, Ermel Raili, Evangelou Evangelos, Franks Paul W, Grace Christopher, Gu Dongfeng, Hingorani Aroon D, Howson Joanna M M, Ingelsson Erik, Kastrati Adnan, Kessler Thorsten, Kyriakou Theodosios, Lehtimäki Terho, Lu Xiangfeng, Lu Yingchang, März Winfried, McPherson Ruth, Metspalu Andres, Pujades-Rodriguez Mar, Ruusalepp Arno, Schadt Eric E, Schmidt Amand F, Sweeting Michael J, Zalloua Pierre A, AlGhalayini Kamal, Keavney Bernard D, Kooner Jaspal S, Loos Ruth J F, Patel Riyaz S, Rutter Martin K, Tomaszewski Maciej, Tzoulaki Ioanna, Zeggini Eleftheria, Erdmann Jeanette, Dedoussis George, Björkegren Johan L M, Schunkert Heribert, Farrall Martin, Danesh John, Samani Nilesh J, Watkins Hugh, Deloukas Panos
Abstract excerpt
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10-8) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5% (refs. 1,2,3,4). Here we leverage an interim release of UK Biobank (UKBB) data to evaluate the validity of the FDR approach. We tested a CAD phenotype inclusive of...
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