Article
Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease.
Circulation - 1 Apr 2008
Schunkert Heribert, Götz Anika, Braund Peter, McGinnis Ralph, Tregouet David-Alexandre, Mangino Massimo, Linsel-Nitschke Patrick, Cambien Francois, Hengstenberg Christian, Stark Klaus, Blankenberg Stefan, Tiret Laurence, Ducimetiere Pierre, Keniry Andrew, Ghori Mohammed J R, Schreiber Stefan, El Mokhtari Nour Eddine, Hall Alistair S, Dixon Richard J, Goodall Alison H, Liptau Henrike, Pollard Helen, Schwarz Daniel F, Hothorn Ludwig A, Wichmann H-Erich, König Inke R, Fischer Marcus, Meisinger Christa, Ouwehand Willem, Deloukas Panos, Thompson John R, Erdmann Jeanette, Ziegler Andreas, Samani Nilesh J
Abstract excerpt
BACKGROUND: Recently, genome-wide association studies identified variants on chromosome 9p21.3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis. METHODS AND RESULTS: A single-nucleotide polymorphism (SNP), rs1333049, representing the 9p21.3 locus, was genotyped in 7 case-control studies involving...
Read the complete abstract on PubMed