Article
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls.
Circulation. Cardiovascular genetics - 1 Oct 2010
Preuss Michael, König Inke R, Thompson John R, Erdmann Jeanette, Absher Devin, Assimes Themistocles L, Blankenberg Stefan, Boerwinkle Eric, Chen Li, Cupples L Adrienne, Hall Alistair S, Halperin Eran, Hengstenberg Christian, Holm Hilma, Laaksonen Reijo, Li Mingyao, März Winfried, McPherson Ruth, Musunuru Kiran, Nelson Christopher P, Burnett Mary Susan, Epstein Stephen E, O'Donnell Christopher J, Quertermous Thomas, Rader Daniel J, Roberts Robert, Schillert Arne, Stefansson Kari, Stewart Alexandre F R, Thorleifsson Gudmar, Voight Benjamin F, Wells George A, Ziegler Andreas, Kathiresan Sekar, Reilly Muredach P, Samani Nilesh J, Schunkert Heribert
Abstract excerpt
BACKGROUND: Recent genome-wide association studies (GWAS) of myocardial infarction (MI) and other forms of coronary artery disease (CAD) have led to the discovery of at least 13 genetic loci. In addition to the effect size, power to detect associations is largely driven by sample size. Therefore, to maximize the chance of finding novel susceptibility loci for CAD and MI, the Coronary ARtery DIsease Genome-wide...
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