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Genetic architecture of coronary artery disease in the genome-wide era: implications for the emerging "golden dozen" loci.

Seminars in thrombosis and hemostasis - 1 Oct 2009

Girelli Domenico, Martinelli Nicola, Peyvandi Flora, Olivieri Oliviero

Abstract excerpt

Clinicians are well aware of family history as a risk factor for coronary artery disease (CAD) and myocardial infarction (MI). The underlying genetic architecture of CAD/MI is extremely complex and still poorly understood. Overall, the genetic heritability of CAD/MI is estimated to be near 40 to 60%. This proportion includes mainly genes that regulate known risk factors (e.g., lipid metabolism) but also genes...

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Identifiers

PMID: 20013534
DOI: 10.1055/s-0029-1242721

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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