Article
New susceptibility locus for coronary artery disease on chromosome 3q22.3.
Nature genetics - 1 Mar 2009
Erdmann Jeanette, Grosshennig Anika, Braund Peter S, König Inke R, Hengstenberg Christian, Hall Alistair S, Linsel-Nitschke Patrick, Kathiresan Sekar, Wright Ben, Trégouët David-Alexandre, Cambien Francois, Bruse Petra, Aherrahrou Zouhair, Wagner Arnika K, Stark Klaus, Schwartz Stephen M, Salomaa Veikko, Elosua Roberto, Melander Olle, Voight Benjamin F, O'Donnell Christopher J, Peltonen Leena, Siscovick David S, Altshuler David, Merlini Piera Angelica, Peyvandi Flora, Bernardinelli Luisa, Ardissino Diego, Schillert Arne, Blankenberg Stefan, Zeller Tanja, Wild Philipp, Schwarz Daniel F, Tiret Laurence, Perret Claire, Schreiber Stefan, El Mokhtari Nour Eddine, Schäfer Arne, März Winfried, Renner Wilfried, Bugert Peter, Klüter Harald, Schrezenmeir Jürgen, Rubin Diana, Ball Stephen G, Balmforth Anthony J, Wichmann H-Erich, Meitinger Thomas, Fischer Marcus, Meisinger Christa, Baumert Jens, Peters Annette, Ouwehand Willem H, Deloukas Panos, Thompson John R, Ziegler Andreas, Samani Nilesh J, Schunkert Heribert
Abstract excerpt
We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive...
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