Article
The Drosophila NR4A nuclear receptor DHR38 regulates carbohydrate metabolism and glycogen storage.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2011
Ruaud Anne-Françoise, Lam Geanette, Thummel Carl S
Abstract excerpt
Animals balance nutrient storage and mobilization to maintain metabolic homeostasis, a process that is disrupted in metabolic diseases like obesity and diabetes. Here, we show that DHR38, the single fly ortholog of the mammalian nuclear receptor 4A family of nuclear receptors, regulates glycogen storage during the larval stages of Drosophila melanogaster. DHR38 is expressed and active in the gut and body wall of...
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