Article
Nuclear receptor DHR96 acts as a sentinel for low cholesterol concentrations in Drosophila melanogaster.
Molecular and cellular biology - 1 Feb 2010
Bujold Mattéa, Gopalakrishnan Akila, Nally Emma, King-Jones Kirst
Abstract excerpt
All eukaryotic cells have to maintain cholesterol concentrations within defined margins in order to function normally. Perturbing cholesterol homeostasis can result in a wide range of cellular and systemic defects, including cardiovascular diseases, as well as Niemann-Pick and Tangier diseases. Here, we show that DHR96 is indispensable for mediating the transcriptional response to dietary cholesterol and that it...
Topics
- Animals
- Cholesterol, Dietary
- Down-Regulation
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation
- Homeostasis
- Larva
- Mutation
- Oligonucleotide Array Sequence Analysis
- Receptors, Cytoplasmic and Nuclear