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Article

Nuclear receptor DHR96 acts as a sentinel for low cholesterol concentrations in Drosophila melanogaster.

Molecular and cellular biology - 1 Feb 2010

Bujold Mattéa, Gopalakrishnan Akila, Nally Emma, King-Jones Kirst

Abstract excerpt

All eukaryotic cells have to maintain cholesterol concentrations within defined margins in order to function normally. Perturbing cholesterol homeostasis can result in a wide range of cellular and systemic defects, including cardiovascular diseases, as well as Niemann-Pick and Tangier diseases. Here, we show that DHR96 is indispensable for mediating the transcriptional response to dietary cholesterol and that it...

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Identifiers

PMID: 19933845
DOI: 10.1128/MCB.01327-09
PMCID: PMC2812236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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