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Article

The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis.

Genes & development - 1 Dec 2009

Horner Michael A, Pardee Keith, Liu Suya, King-Jones Kirst, Lajoie Gilles, Edwards Aled, Krause Henry M, Thummel Carl S

Abstract excerpt

Cholesterol homeostasis is required to maintain normal cellular function and avoid the deleterious effects of hypercholesterolemia. Here we show that the Drosophila DHR96 nuclear receptor binds cholesterol and is required for the coordinate transcriptional response of genes that are regulated by cholesterol and involved in cholesterol uptake, trafficking, and storage. DHR96 mutants die when grown on low levels of...

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Identifiers

PMID: 19952106
DOI: 10.1101/gad.1833609
PMCID: PMC2788327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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