Article
The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth.
Cell metabolism - 2 Feb 2011
Tennessen Jason M, Baker Keith D, Lam Geanette, Evans Janelle, Thummel Carl S
Abstract excerpt
Metabolism must be coordinated with development to provide the appropriate energetic needs for each stage in the life cycle. Little is known, however, about how this temporal control is achieved. Here, we show that the Drosophila ortholog of the estrogen-related receptor (ERR) family of nuclear receptors directs a critical metabolic transition during development. dERR mutants die as larvae with low ATP levels and...
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