Article
Statistical design of personalized medicine interventions: the Clarification of Optimal Anticoagulation through Genetics (COAG) trial.
Trials - 17 Nov 2010
French Benjamin, Joo Jungnam, Geller Nancy L, Kimmel Stephen E, Rosenberg Yves, Anderson Jeffrey L, Gage Brian F, Johnson Julie A, Ellenberg Jonas H
Abstract excerpt
BACKGROUND: There is currently much interest in pharmacogenetics: determining variation in genes that regulate drug effects, with a particular emphasis on improving drug safety and efficacy. The ability to determine such variation motivates the application of personalized drug therapies that utilize a patient's genetic makeup to determine a safe and effective drug at the correct dose. To ascertain whether a...
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