Article
Rationale and design of the Clarification of Optimal Anticoagulation through Genetics trial.
American heart journal - 1 Sept 2013
Kimmel Stephen E, French Benjamin, Anderson Jeffrey L, Gage Brian F, Johnson Julie A, Rosenberg Yves D, Geller Nancy L, Kasner Scott E, Eby Charles S, Joo Jungnam, Caldwell Michael D, Goldhaber Samuel Z, Hart Robert G, Cifelli Denise, Madigan Rosemary, Brensinger Colleen M, Goldberg Suzanne, Califf Robert M, Ellenberg Jonas H
Abstract excerpt
BACKGROUND: Current dosing practices for warfarin are empiric and result in the need for frequent dose changes as the international normalized ratio gets too high or too low. As a result, patients are put at increased risk for thromboembolism, bleeding, and premature discontinuation of anticoagulation therapy. Prior research has identified clinical and genetic factors that can alter warfarin dose requirements,...
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