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Article

Impact of genotype-guided dosing on anticoagulation visits for adults starting warfarin: a randomized controlled trial.

Pharmacogenomics - 1 Oct 2013

Jonas Daniel E, Evans James P, McLeod Howard L, Brode Shannon, Lange Leslie A, Young Mary L, Shilliday Betsy Bryant, Bardsley Michelle Martensen, Swinton-Jenkins Nia J, Weck Karen E

Abstract excerpt

AIM: This study aimed to assess the effectiveness of genotype-guided warfarin dosing. PATIENTS & METHODS: A total of 109 adults were randomized to receive initial dosing as determined by an algorithm containing genetic (VKORC1 and CYP2C9) plus clinical information or only clinical information. Primary end points were the number of anticoagulation visits and the time in therapeutic range (TTR) over 90 days....

Read the complete abstract on PubMed

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Share to Anticoagulants
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Coagulation

Share to Cytochrome P-450 CYP2C9

Share to Dose-Response Relationship, Drug

Share to International Normalized Ratio

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Identifiers

PMID: 24088130
DOI: 10.2217/pgs.13.145

Genes

TTR
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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