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Article

Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation.

Circulation - 27 Nov 2007

Anderson Jeffrey L, Horne Benjamin D, Stevens Scott M, Grove Amanda S, Barton Stephanie, Nicholas Zachery P, Kahn Samera F S, May Heidi T, Samuelson Kent M, Muhlestein Joseph B, Carlquist John F

Abstract excerpt

BACKGROUND: Pharmacogenetic-guided dosing of warfarin is a promising application of "personalized medicine" but has not been adequately tested in randomized trials. METHODS AND RESULTS: Consenting patients (n=206) being initiated on warfarin were randomized to pharmacogenetic-guided or standard dosing. Buccal swab DNA was genotyped for CYP2C9 *2 and CYP2C9 *3 and VKORC1C1173T with a rapid assay. Standard dosing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17989110
DOI: 10.1161/CIRCULATIONAHA.107.737312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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