Article
A pharmacogenetic versus a clinical algorithm for warfarin dosing.
The New England journal of medicine - 12 Dec 2013
Kimmel Stephen E, French Benjamin, Kasner Scott E, Johnson Julie A, Anderson Jeffrey L, Gage Brian F, Rosenberg Yves D, Eby Charles S, Madigan Rosemary A, McBane Robert B, Abdel-Rahman Sherif Z, Stevens Scott M, Yale Steven, Mohler Emile R, Fang Margaret C, Shah Vinay, Horenstein Richard B, Limdi Nita A, Muldowney James A S, Gujral Jaspal, Delafontaine Patrice, Desnick Robert J, Ortel Thomas L, Billett Henny H, Pendleton Robert C, Geller Nancy L, Halperin Jonathan L, Goldhaber Samuel Z, Caldwell Michael D, Califf Robert M, Ellenberg Jonas H
Abstract excerpt
BACKGROUND: The clinical utility of genotype-guided (pharmacogenetically based) dosing of warfarin has been tested only in small clinical trials or observational studies, with equivocal results. METHODS: We randomly assigned 1015 patients to receive doses of warfarin during the first 5 days of therapy that were determined according to a dosing algorithm that included both clinical variables and genotype data or...
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