Article
Pharmacogenetics in randomized controlled trials: considerations for trial design.
Pharmacogenomics - 1 Oct 2011
van der Baan Frederieke H, Klungel Olaf H, Egberts Antoine C G, Leufkens Hubert G, Grobbee Diederick E, Roes Kit C B, Knol Mirjam J
Abstract excerpt
Pharmacogenetic analyses of clinical trials aim to either detect whether a subgroup of patients identified by genetic characteristics responds differently to the treatment or to verify whether a proposed genotype-guided treatment is beneficial over standard care. This article describes three different trial designs, differing in the timing of randomization and genotyping. Each design has its own advantages, and...
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