Article
Effect of Genotype-Guided Warfarin Dosing on Clinical Events and Anticoagulation Control Among Patients Undergoing Hip or Knee Arthroplasty: The GIFT Randomized Clinical Trial.
JAMA - 26 Sept 2017
Gage Brian F, Bass Anne R, Lin Hannah, Woller Scott C, Stevens Scott M, Al-Hammadi Noor, Li Juan, Rodríguez Tomás, Miller J Philip, McMillin Gwendolyn A, Pendleton Robert C, Jaffer Amir K, King Cristi R, Whipple Brandi DeVore, Porche-Sorbet Rhonda, Napoli Lynnae, Merritt Kerri, Thompson Anna M, Hyun Gina, Anderson Jeffrey L, Hollomon Wesley, Barrack Robert L, Nunley Ryan M, Moskowitz Gerard, Dávila-Román Victor, Eby Charles S
Abstract excerpt
Importance: Warfarin use accounts for more medication-related emergency department visits among older patients than any other drug. Whether genotype-guided warfarin dosing can prevent these adverse events is unknown. Objective: To determine whether genotype-guided dosing improves the safety of warfarin initiation. Design, Setting, and Patients: The randomized clinical Genetic Informatics Trial (GIFT) of Warfarin...
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