Article
A homolog of Drosophila grainy head is essential for epidermal integrity in mice.
Science (New York, N.Y.) - 15 Apr 2005
Ting Stephen B, Caddy Jacinta, Hislop Nikki, Wilanowski Tomasz, Auden Alana, Zhao Lin-Lin, Ellis Sarah, Kaur Pritinder, Uchida Yoshikazu, Holleran Walter M, Elias Peter M, Cunningham John M, Jane Stephen M
Abstract excerpt
The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly. Integral to cuticle resilience is the transcription factor grainy head, which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy...
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