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Article

Genome-wide association study to identify novel loci associated with therapy-related myeloid leukemia susceptibility.

Blood - 28 May 2009

Knight Jeffrey A, Skol Andrew D, Shinde Abhijit, Hastings Darcie, Walgren Richard A, Shao Jin, Tennant Thelma R, Banerjee Mekhala, Allan James M, Le Beau Michelle M, Larson Richard A, Graubert Timothy A, Cox Nancy J, Onel Kenan

Abstract excerpt

Therapy-related acute myeloid leukemia (t-AML) is a rare but fatal complication of cytotoxic therapy. Whereas sporadic cancer results from interactions between complex exposures and low-penetrance alleles, t-AML results from an acute exposure to a limited number of potent genotoxins. Consequently, we hypothesized that the effect sizes of variants associated with t-AML would be greater than in sporadic cancer,...

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Identifiers

PMID: 19299336
DOI: 10.1182/blood-2008-10-183244
PMCID: PMC2689055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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