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Article

Genomic and genome-wide association of susceptibility to radiation-induced fibrotic lung disease in mice.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Dec 2012

Paun Alexandra, Haston Christina K

Abstract excerpt

BACKGROUND AND PURPOSE: To identify genes which influence the fibrotic response to thoracic cavity radiotherapy, we combined a genome wide single nucleotide polymorphism (SNP) association evaluation of inbred strain response with prior linkage and gene expression data. MATERIAL AND METHODS: Mice were exposed to 18Gy whole thorax irradiation and survival, bronchoalveolar cell differential, and histological...

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PMID: 22954495
DOI: 10.1016/j.radonc.2012.08.004

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