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Article

Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice.

Blood - 15 Aug 2008

Funk Ryan K, Maxwell Taylor J, Izumi Masayo, Edwin Deepa, Kreisel Friederike, Ley Timothy J, Cheverud James M, Graubert Timothy A

Abstract excerpt

Therapy-related acute myelogenous leukemia (t-AML) is an important late adverse effect of alkylator chemotherapy. Susceptibility to t-AML has a genetic component, yet specific genetic variants that influence susceptibility are poorly understood. We analyzed an F(2) intercross (n = 282 mice) between mouse strains resistant or susceptible to t-AML induced by the alkylator ethyl-N-nitrosourea (ENU) to identify genes...

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Share to Alkylating Agents
Share to Leukemia, Myeloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Promyelocytic, Acute

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Source

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Identifiers

PMID: 18552208
DOI: 10.1182/blood-2008-01-132084
PMCID: PMC2515115

Genes

PML
RARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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